SML2235

CL075

≥98% (HPLC)

• 別名: 2-Propylthiazolo[4,5-c]quinolin-4-amine, 3M002
• 実験式（ヒル表記法）: C₁₃H₁₃N₃S
• CAS番号: 256922-53-9
• 分子量: 243.33
• MDL番号: MFCD09998898
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• InChI: 1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)
• InChI Key: NFYMGJSUKCDVJR-UHFFFAOYSA-N

詳細

アプリケーション

CL075 has been used to activate the monocyte-derived dendritic cells (DCs) to demonstrate the ability of DCs to induce cell death.

生物化学的／生理学的作用

CL075 is a selective agonist of Toll-like receptor-8 (TLR-8) with immunostimulant activity. It showed an EC50 value of 400nM for IRF-NFΚB stimulation in TLR8 compared to 4 μM for TLR7.

CL075 is a thiazoloquinolone derivative. It might influence tumor development.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable