SML3782

Omadacycline tosylate

≥97% (HPLC)

• 別名: MK-2764 tosylate, (4S,4aS,5aR,12aS)-4,7-bis(Dimethylamino)-9-(2,2-dimethylpropylaminomethyl)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12aoctahydrotetracene-2-carboxamide, 4-methylbenzenesulfonate, Amadacycline tosylate, BAY 73-7388 tosylate, MK 2764 tosylate, MK2764 tosylate, PTK 0796 tosylate, PTK-0796 tosylate, PTK0796 tosylate
• 実験式（ヒル表記法）: C₂₉H₄₀N₄O₇·C₇H₈O₃S
• CAS番号: 1075240-43-5
• 分子量: 728.85
• MDL番号: MFCD28167752
• UNSPSCコード: 51111800
• UNSPSCコード: 12352200
• NACRES: NA.21

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: powder
• 保管条件: desiccated
• 色: yellow to orange
• 溶解性: H₂O: 2 mg/mL, clear
• 保管温度: -10 to -25°C

詳細

生物化学的／生理学的作用

Omadacycline (amadacycline, PTK 0796) is an orally active, potent tetracycline-class antibacterial against broad gram-positive and some gram-negative bacteria, including strains expressing the two main forms of tetracycline resistance (efflux and ribosomal protection). Omadacycline is also active against Haemophilus influenzae (H. influenzae) and atypical and anaerobic pathogens, including Legionella pneumophila, Mycoplasma spp., Ureaplasma spp., Bacteroides spp., and Clostridioides difficile. Unlike tetracycline, Omadacycline is active in vitro in the presence of the ribosomal protection protein Tet(O), despite its ribosomal binding site is similar to that of tetracycline.

注意

Hygroscopic

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Warning
• 危険有害性情報: H361d,H362
• 注意書き: P202 - P260 - P263 - P264 - P280 - P308 + P313
• 危険有害性の分類: Lact. - Repr. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable