SML3753

TH301

≥98% (HPLC)

• 別名: 1-​(4-​Chlorophenyl)​-​N-​[2,​6-​dihydro-​2-​(4-​methoxyphenyl)​-​5,​5-​dioxido-​4H-​thieno[3,​4-​c]​pyrazol-​3-​yl]​-cyclopentanecarboxam​ide
• 実験式（ヒル表記法）: C₂₄H₂₄ClN₃O₄S
• CAS番号: 450338-32-6
• 分子量: 485.98
• UNSPSCコード: 12352200
• NACRES: NA.21

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=C(C1(CCCC1)C2=CC=C(Cl)C=C2)NC3=C(CS(C4)(=O)=O)C4=NN3C5=CC=C(OC)C=C5
• InChI: 1S/C24H24ClN3O4S/c1-32-19-10-8-18(9-11-19)28-22(20-14-33(30,31)15-21(20)27-28)26-23(29)24(12-2-3-13-24)16-4-6-17(25)7-5-16/h4-11H,2-3,12-15H2,1H3,(H,26,29)
• InChI Key: DDCUCVXSGYHWRJ-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Circadian clock modulator that selectively stabilizes CRY2

TH301 is a circadian clock modulator that lengthens a circadian period in cells and tissues. It selectively stabilizes CRY2 through interaction with FAD-binding pocket. TH301 strongly enhanced brown adipocyte differentiation in culture. TH301 showed no or only minor effects on CKIδ, CKIα and CK2 activities in vitro.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable