SML3744

Ac-FLTD-CMK

≥95% (HPLC)

• 別名: N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone
• 実験式（ヒル表記法）: C₂₆H₃₇ClN₄O₈
• CAS番号: 2376255-48-8
• 分子量: 569.05
• MDL番号: MFCD32874101
• UNSPSCコード: 51111800
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: (Powder or Lyophilized powder or film)
• 保管条件: desiccated
• 色: white to off-white
• 保管温度: -10 to -25°C

詳細

生物化学的／生理学的作用

Ac-FLTD-CMK is a selective gasdermin D (GSDMD) clevage inhibitor (IC50 = 46.7 nM, 329 nM, 1.49 μM, respectively, against GSDMD clevage by human caspase-1, -5, -4 in cell-free enzymatic assays) that suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages (10 μM 4h post 200 ng/mL LPS and 0.5h before ATP or nigericin). Ac-FLTD-CMK selectively blocks GSDMD clevage by inflammatory caspases without affecting apoptotic caspases (caspase-3 IC50 >100 μM) or apoptosis.

注意

Hygroscopic

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable