SML3742

GK13S

≥98% (HPLC)

• 別名: (S)-1-Cyano-N-(1-(4-(pent-4-yn-1ylcarbamoyl)phenyl)-1H-imidazol-4-yl)pyrrolidine-3-carboxamide
• 実験式（ヒル表記法）: C₂₁H₂₂N₆O₂
• 分子量: 390.44
• MDL番号: MFCD35067861
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: -10 to -25°C
• SMILES記法: [n]2(cnc(c2)NC(=O)[C@@H]3CN(CC3)C#N)c1ccc(cc1)C(=O)NCCCC#C
• InChI: 1S/C21H22N6O2/c1-2-3-4-10-23-20(28)16-5-7-18(8-6-16)27-13-19(24-15-27)25-21(29)17-9-11-26(12-17)14-22/h1,5-8,13,15,17H,3-4,9-12H2,(H,23,28)(H,25,29)/t17-/m0/s1
• InChI Key: LSHAYFDZIOIKII-KRWDZBQOSA-N

詳細

生物化学的／生理学的作用

Cell penetrant, potent and non-toxic activity-based probe for deubiquitinase UCHL1; chemogenomic probe suitable for the cellular study of UCHL1.


GK13S is a cell penetrant, potent and non-toxic activity-based probe for deubiquitinase UCHL1. GK13S, but not GK16S, led to the reduction of monoubiquitin levels in the human glioblastoma cell line U-87 MG. GK13S together with GK16S comprises a set of chemogenomic probes for UCHL1, which is suitable for investigation of cellular functions of UCHL. GK13S also binds to PARK7, C21orf33, ISOC1 andNIT2.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable