SML3644

JR-AB2-011

≥98% (HPLC)

• 別名: 3-(3,4-Dichlorophenyl)-1-(4-fluorophenyl)-1-(5-methyl-4,5-dihydrothiazol-2-yl)urea, N-(3,4-Dichlorophenyl)-2-[(4-fluorophenyl)imino]-5-methyl-3-thiazolidinecarboxamide
• 実験式（ヒル表記法）: C₁₇H₁₄Cl₂FN₃OS
• CAS番号: 2411853-34-2
• 分子量: 398.28
• MDL番号: MFCD32062799
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear (Warmed)
• 保管温度: 2-8°C

詳細

生物化学的／生理学的作用

JR-AB2-011 is a selective mTORC2 inhibitor that blocks the interaction of Rictor and mTOR (IC50 = 0.31 µM) without affecing mTORC1 activity or assembly. JR-AB2-011 exhibits anti-glioblastoma (GBM) activity in vitro (proliferation IC50 = 0.31 µM post 72h treatment, 36.3% apoptosis post 48h 1 µM treatment in LN229 cultures) and in vivo (4 or 20 mg/kg/d i.p. to LN229 xenografted mice).

Selective mTORC2 inhibitor with anti-GBM efficacy in vitro and in vivo by blocking Rictor and mTOR interaction.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable