SML3478

PNU-159682

≥95% (HPLC)

• 別名: (8S,10S)-7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4′,3′:4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-5,12-naphthacenedione, PNU 159682
• 実験式（ヒル表記法）: C₃₂H₃₅NO₁₃
• CAS番号: 202350-68-3
• 分子量: 641.62
• MDL番号: MFCD12756329
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: powder
• 保管条件: under inert gas
• 色: , Faint red to very dark red
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: -10 to -25°C

詳細

生物化学的／生理学的作用

PNU-159682, an active nemorubicin metabolite, is a highly potent anthracycline toxin that retains antitumor activity in vivo. Similarly to other anthracyclines PNU-159682 intercalates between the CG base pairs of DNA, but the stability of the complexes is much higher.

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H301,H341,H351,H360FD
• 注意書き: P202 - P264 - P270 - P280 - P301 + P310 - P405
• 危険有害性の分類: Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable