SML3413

ASC-J9

≥98% (HPLC)

• 別名: (1E, 4Z, 6E)-5-Hydroxy-1,7-bis(3,4-dimethoxyphenyl)-1,4,6-heptatrien-3-one, Dimethylcurcumin, GO-Y025
• 実験式（ヒル表記法）: C₂₃H₂₄O₆
• CAS番号: 52328-98-0
• 分子量: 396.43
• MDL番号: MFCD28964095
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: desiccated
• 色: , White to light orange
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: OC(/C=C/C1=CC(OC)=C(C=C1)OC)=C\C(/C=C/C2=CC(OC)=C(C=C2)OC)=O
• InChI: 1S/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-15,24H,1-4H3/b9-5+,10-6+,18-15-
• InChI Key: ZMGUKFHHNQMKJI-CIOHCNBKSA-N

詳細

生物化学的／生理学的作用

ASC-J9 (dimethylcurcumin) is an androgen receptor (AR)-selective degradation promoter that disrupts the interaction between AR and its coregulators. ASC-J9 induces AR degration in cultures (5 µM, LNCaP) and shows in vivo therapeutic efficacy (50 mg/kg i.p. qod) in murine bladder cancer (TCC-SUP and UMUC3 xenografts) and a spinal and bulbar muscular atrophy disease model (AR-polyQ transgenic SBMA mice).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable