SML3341

ML-SA5

≥98% (HPLC)

• 別名: N1-(3-Chloro-2-(piperidin-1-yl)phenyl)-N4,N4-dimethylbenzene-1,4-disulfonamide
• 実験式（ヒル表記法）: C₁₉H₂₄ClN₃O₄S₂
• CAS番号: 2418670-70-7
• 分子量: 457.99
• MDL番号: MFCD32679424
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: desiccated
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: −20°C

詳細

生物化学的／生理学的作用

ML-SA5 is a potent TRPML cation channel agonist that activates whole-endolysosomal TRPML1 (ML1) currents in DMD myoblasts at a higher potency than ML-SA1 (EC50 = 285 nM vs 10 μM). ML-SA5 ameliorates muscular dystrophy in mdx, but not ML1-knockout, mice in vivo (2 or 5 mg/kg/day i.p.) by facilitating sarcolemma repair, thereby reducing skeletal and cardiac muscle damage with no apparent toxicity to the animals.

Potent TRPML1 cation channel agonist that ameliorates muscular dystrophy in mdx, but not ML1-KO, mice and with a higher potency than ML-SA1.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable