SML1509

MK6-83

≥98% (HPLC)

• 別名: 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
• 実験式（ヒル表記法）: C₁₆H₂₀N₂O₂S₂
• CAS番号: 1062271-24-2
• 分子量: 336.47
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to brown
• 溶解性: DMSO: 5 mg/mL, clear (warmed)
• 保管温度: 2-8°C
• InChI: 1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3
• InChI Key: IRGYSXZCDAWOOC-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.

MK6-83 is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable