SML2617

Celiprolol hydrochloride

≥98% (HPLC)

• 別名: Celiprolol hydrochloride, (3-[3-Acetyl-4-(3-t-butylamino-2-hydroxypropoxy)phenyl]-2,1-diethylurea hydrochloride, NSC 324509, REV 5320A, ST 1396, Selecor, Tenoloc
• 実験式（ヒル表記法）: C₂₀H₃₃N₃O₄ · HCl
• CAS番号: 57470-78-7
• 分子量: 415.95
• MDL番号: MFCD00941500
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: H₂O: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: [Cl-].N(CC)(CC)C(=O)Nc1cc(c(cc1)OCC(O)CNC(C)(C)C)C(=O)C.[H+]
• InChI: 1S/C20H33N3O4.ClH/c1-7-23(8-2)19(26)22-15-9-10-18(17(11-15)14(3)24)27-13-16(25)12-21-20(4,5)6;/h9-11,16,21,25H,7-8,12-13H2,1-6H3,(H,22,26);1H
• InChI Key: VKJHTUVLJYWAEY-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Celiprolol is a selective adrenoceptor modulator that acts not only as a selective β₁ receptor antagonist, but also as a β₂ receptor partial agonist. Because of its of its β₂ agonist activity, celiprolol lacks the typical side effects of the beta-blockers, such as bronchoconstriction, depression of left ventricular function, and peripheral vasoconstriction, making it a good candidate for patients with both cardiovascular and pulmonary disease. It is currently being investigated for treatment of vascular Ehlers-Danlos Syndrome (vEDS).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable