SML2594

Sapacitabine

• 別名: CS 682, CYC 682, N-[1-(2-Cyano-2-deoxy-β-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyrimidinyl]hexadecanamide
• 実験式（ヒル表記法）: C₂₆H₄₂N₄O₅
• CAS番号: 151823-14-2
• 分子量: 490.64
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥95% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: N1\C(=N\C(=O)CCCCCCCCCCCCCCC)\C=CN(C1=O)[C@@H]2O[C@@H]([C@H]([C@@H]2C#N)O)CO
• InChI: 1S/C26H42N4O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-23(32)28-22-16-17-30(26(34)29-22)25-20(18-27)24(33)21(19-31)35-25/h16-17,20-21,24-25,31,33H,2-15,19H2,1H3,(H,28,29,32,34)/t20-,21+,24-,25+/m0/s1
• InChI Key: LBGFKUUHOPIEMA-PEARBKPGSA-N

詳細

生物化学的／生理学的作用

Sapacitabine is an orally active prodrug of nucleoside analog CNDAC that exhibits potent anti-tumor activity in both blood and solid tumors. CNDAC incorporates into DNA where it causes single-strand breaks (SSBs), which are converted into double strand breaks (DSBs) during S phase.

orally active prodrug of nucleoside analog CNDAC that incorporates into DNA where it causes single-strand breaks

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable