SML2221

CU-CPT9a

≥98% (HPLC)

• 別名: 2-Methyl-4-(7-methoxyl-4-quinolinyl)-phenol, Phenol, 4-(7-methoxy-4-quinolinyl)-2-methyl
• 実験式（ヒル表記法）: C₁₇H₁₅NO₂
• CAS番号: 2165340-32-7
• 分子量: 265.31
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: CC1=CC(C2=CC=NC3=CC(OC)=CC=C23)=CC=C1O
• InChI: 1S/C17H15NO2/c1-11-9-12(3-6-17(11)19)14-7-8-18-16-10-13(20-2)4-5-15(14)16/h3-10,19H,1-2H3
• InChI Key: HNYBTVKYLVLWCB-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

CU-CPT9a is a potent and selective inhibitor of Toll-like receptor 8 (TLR8). It binds to TLR8 at a site different from current small-molecule TLR7/8 agonists, stabilizing the TLR8 dimer in its resting state, thus preventing TLR8 activation It exhibited an IC50 value of 0.5 nM and blocked TLR8 activation induced by either resiquimod (R848) or ssRNA without affecting the closely related TLR7 or cells expressing other TLRs. CU-CPT9a also suppressed TNF-α levels in a dose-dependent manner in cells from patients with rheumatoid arthritis.

Inhibitor of Toll-like receptor 8 (TLR8)

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable