SML1744

A-971432

≥95% (HPLC)

• 別名: 1-(4-(3,4-Dichlorobenzyloxy)benzyl)azetidine-3-carboxylic acid
• 実験式（ヒル表記法）: C₁₈H₁₇Cl₂NO₃
• CAS番号: 1240308-45-5
• 分子量: 366.24
• MDL番号: MFCD30182357
• UNSPSCコード: 12352200
• PubChem Substance ID: 329826050
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 3 mg/mL, clear (warmed)
• 保管温度: 2-8°C
• SMILES記法: ClC1=CC(COC2=CC=C(CN3CC(C(O)=O)C3)C=C2)=CC=C1Cl
• InChI: 1S/C18H17Cl2NO3/c19-16-6-3-13(7-17(16)20)11-24-15-4-1-12(2-5-15)8-21-9-14(10-21)18(22)23/h1-7,14H,8-11H2,(H,22,23)

詳細

生物化学的／生理学的作用

A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC₅₀ = 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay) without affect the activity of 129 protein kinases (IC₅₀ >10 μM). A-971432 is shown to enhance blood-brain barrier integrity and reverse lipid accumulation and age-related cognitive decline in mice in vivo with good pharmacokinetics (t_1/2  = 5.7 h; C_max = 2,500 ng/ml; AUC = 35,000 ng.h/ml at 10 mg/kg, p.o. in CD1 mice). Likewise, oral gavage showed good plasma exposure and no sign of lymphopenia in rats (10, 30, and 100 mg/kg.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319
• 注意書き: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable