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生物化学的／生理学的作用
FIN56 is a specific inducer of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS). FIN56 has an EC50 value of 240 nM, and is believed to act though two separate pathways. The first requires the enzymatic activity of acetyl-CoA carboxylase (ACC),and results in degradation of glutathione peroxidase 4 (GPX4), which acts as a negative regulator of ferroptosis by reducing lipid hydroperoxides. The second pathway involves FIN56 binding to and activing squalene synthase, which leads to coenzyme Q10 depletion.
Ferroptosis inducer 56 (FIN56) is a member of the class 3 ferroptosis inducers.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
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Unsolved mysteries: How does lipid peroxidation cause ferroptosis?.
Feng H and Stockwell BR
PLoS Biology, 16(5), e2006203-e2006203 (2018)
Po-Han Chen et al.
Cell death and differentiation, 27(3), 1008-1022 (2019-07-20)
Ferroptosis is a specialized iron-dependent cell death that is associated with lethal lipid peroxidation. Modulation of ferroptosis may have therapeutic potential since it has been implicated in various human diseases as well as potential antitumor activities. However, much remains unknown
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