SML1711

TNCA

≥98% (HPLC)

• 別名: (3S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid, L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid, Lycoperodine-1
• 実験式（ヒル表記法）: C₁₂H₁₂N₂O₂
• CAS番号: 42438-90-4
• 分子量: 216.24
• MDL番号: MFCD00272641
• UNSPSCコード: 12352200
• PubChem Substance ID: 329826033
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 光学活性: [α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))
• 色: white to beige
• 溶解性: 1.5 mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)
• 保管温度: −20°C
• SMILES記法: O=C(O)[C@H]1NCC2=C(C3=C(N2)C=CC=C3)C1
• InChI: 1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16)/t10-/m0/s1
• InChI Key: FSNCEEGOMTYXKY-JTQLQIEISA-N

詳細

生物化学的／生理学的作用

TNCA is a tryptophan derivative that binds the parathyroid Ca²⁺-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable