SML1573

Tolrestat

≥98% (HPLC)

• 別名: AY-27773, CID 53359, N-[[5 -(Trifluoromethyl)-6-methoxy-lnaphthalenyl]thioxomethyl]-N-methylglycine, N-[[6-Methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methyl-glycine, Tolrestatin
• 実験式（ヒル表記法）: C₁₆H₁₄F₃NO₃S
• CAS番号: 82964-04-3
• 分子量: 357.35
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: FC(F)(F)c1c2c(c(ccc2)C(=S)N(CC(=O)O)C)ccc1OC
• InChI: 1S/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22)
• InChI Key: LUBHDINQXIHVLS-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Tolrestat is an orally active and potent aldose reductase inhibitor. Studies have also shown that it reduces RBC (red blood cells) sorbitol levels in rats.

Tolrestat is considered to be effective in treating the consequences of diabetes including neuropathy, nephropathy, retinopathy and esophageal motility and vibration perception. Tolrestat is also believed to have lesser or no toxic effects.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3