SML1452

Ibufenac

≥95% (HPLC)

• 別名: 4-(2-Methylpropyl)-benzeneacetic acid, 4-Isobutylphenylacetic acid
• 実験式（ヒル表記法）: C₁₂H₁₆O₂
• CAS番号: 1553-60-2
• 分子量: 192.25
• EC Number: 216-302-2
• MDL番号: MFCD00864374
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825891
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: OC(CC1=CC=C(CC(C)C)C=C1)=O
• InChI: 1S/C12H16O2/c1-9(2)7-10-3-5-11(6-4-10)8-12(13)14/h3-6,9H,7-8H2,1-2H3,(H,13,14)
• InChI Key: CYWFCPPBTWOZSF-UHFFFAOYSA-N
• 遺伝子情報: human ... PTGS1(5742) , PTGS2(5743)

詳細

生物化学的／生理学的作用

Ibufenac is a non-steroidal anti-inflammatory drug (NSAID) analog of ibuprofen that was withdrawn for hepatotoxicity. It inhibits cyclooxygenases COX-1 and -2 activity with IC50 values of 17.4 and 13.1 μM, respectively and > 40 μM for 5-LOX. It has been used in studies of drug-induced hepatotoxicity.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable