SML1560

Azoramide

≥98% (HPLC)

• 別名: N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]-butanamide, N-{2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]ethyl} butanamide
• 実験式（ヒル表記法）: C₁₅H₁₇ClN₂OS
• CAS番号: 932986-18-0
• 分子量: 308.83
• MDL番号: MFCD08009374
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825964
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 30 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: ClC1=CC=C(C2=NC(CCNC(CCC)=O)=CS2)C=C1
• InChI: 1S/C15H17ClN2OS/c1-2-3-14(19)17-9-8-13-10-20-15(18-13)11-4-6-12(16)7-5-11/h4-7,10H,2-3,8-9H2,1H3,(H,17,19)
• InChI Key: VYBFWKKCWTXCQX-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It has dual activity: Azoramide improves endoplasmic reticulum (ER) protein-folding ability and stimulates the expression of ER chaperones that protect cells against ER stress. Azoramide was shown to protect cells from death and dysfunction in multiple models of ER stress. It showed antidiabetic activity in two independent mouse models of obesity by improving insulin sensitivity and protecting pancreatic β cell function against ER stress.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable