SML1492

UMI-77

≥98% (HPLC)

• 別名: 2-[[4-[[(4-Bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid
• 実験式（ヒル表記法）: C₁₈H₁₄BrNO₅S₂
• CAS番号: 518303-20-3
• 分子量: 468.34
• MDL番号: MFCD03471890
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825918
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: OC1=C(SCC(O)=O)C=C(NS(C2=CC=C(Br)C=C2)(=O)=O)C3=CC=CC=C31
• InChI: 1S/C18H14BrNO5S2/c19-11-5-7-12(8-6-11)27(24,25)20-15-9-16(26-10-17(21)22)18(23)14-4-2-1-3-13(14)15/h1-9,20,23H,10H2,(H,21,22)
• InChI Key: WUGANDSUVKXMEC-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

UMI-77 is an inhibitor of Induced myeloid leukemia cell differentiation protein Mcl-1, a member of the Bcl-2 family that inhibits apoptosis. UMI-77 acts by binding to the BH3-binding groove of Mcl-1, blocking the heterodimerization of Mcl-1/Bax and Mcl-1/Bak. UMI-77 is selective for Mcl-1 over other members of the antiapoptotic Bcl-2 family with a Ki of 490 nM. It inhibited cell growth and induced apoptosis in pancreatic cancer cells.

安全性情報

• ピクトグラム: GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302 - H315 - H318 - H335
• 注意書き: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable