SML0853

SB 699551 dihydrochloride

≥98% (HPLC)

• 別名: N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride
• 実験式（ヒル表記法）: C₃₄H₄₅N₃O · 2HCl
• CAS番号: 864741-95-7
• 分子量: 584.66
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: H₂O: 1 mg/mL, clear (warmed)
• 保管温度: 2-8°C
• SMILES記法: Cl.Cl.N(CCN(Cc2ccc(cc2)c3ccc(cc3)CNCCc4ccccc4)C(=O)CCC1CCCC1)(C)C
• InChI: 1S/C34H45N3O.2ClH/c1-36(2)24-25-37(34(38)21-16-28-10-6-7-11-28)27-31-14-19-33(20-15-31)32-17-12-30(13-18-32)26-35-23-22-29-8-4-3-5-9-29;;/h3-5,8-9,12-15,17-20,28,35H,6-7,10-11,16,21-27H2,1-2H3;2*1H
• InChI Key: QJMKBIHLMPTYTI-UHFFFAOYSA-N

詳細

アプリケーション

SB 699551 dihydrochloride has been used to identify the antagonism of 5-HT2AR in cell culture-derived hepatitis C virus (HCVcc).

生物化学的／生理学的作用

SB 699551 dihydrochloride is also known as (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4′-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride). It is considered as a useful tool to explain the physiological roles of the 5-ht5A receptor.

SB-699551 is 5-HT5A receptor antagonist.

SB-699551 is a 5-HT5A receptor antagonist, (pKi = 8.3) with 100-fold selectivity over other 5-HT receptor populations. SB-699551 completely blocks 5-HT-induced [35S]GTPγS membrane binding in cells expressing recombinant guinea pig 5-HT-5A.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable