SML0435

AF-DX 116

≥98% (HPLC)

• 別名: 11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,1 1-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, Otenzepad
• 実験式（ヒル表記法）: C₂₄H₃₁N₅O₂
• CAS番号: 102394-31-0
• 分子量: 421.54
• MDL番号: MFCD00864743
• UNSPSCコード: 12352200
• PubChem Substance ID: 329824718
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 薬剤管理: regulated under CDSA - not available from Sigma-Aldrich Canada
• 色: white to beige
• 溶解性: DMSO: 5 mg/mL (clear solution; warmed)
• 保管温度: room temp
• SMILES記法: CCN(CC)CC1CCCCN1CC(=O)N2c3ccccc3C(=O)Nc4cccnc24
• InChI: 1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)
• InChI Key: UBRKDAVQCKZSPO-UHFFFAOYSA-N

詳細

アプリケーション

AF-DX 116 has been used as an M2 muscarinic acetylcholine receptor (M2AChR) selective antagonist to study the influence of M2AChR in the regulation of both basal and carbachol-stimulated long-term potentiation at the dentate gyrus (DG-LTP) and pro-nerve growth factor (proNGF) secretion in hippocampal cells of young diabetic rats.

生物化学的／生理学的作用

AF-DX 116 is a selective M2 muscarinic acetylcholine receptor antagonist.

AF-DX 116 raises blood pressure and heart rate in a rat model of hypotension induced by repeated cold stress. Thus, it may be used as a therapeutic for hypotension related to vagotonia type autonomic dysfunction.

特徴および利点

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable