SML0208

KYP-2047

≥95% (HPLC)

• 別名: (2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
• 実験式（ヒル表記法）: C₂₀H₂₅N₃O₂
• CAS番号: 796874-99-2
• 分子量: 339.43
• MDL番号: MFCD22201003
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825230
• NACRES: NA.77

特性

• アッセイ: ≥95% (HPLC)
• 形状: oil
• 保管条件: desiccated
• 色: white to light brown
• 保管温度: 2-8°C
• SMILES記法: O=C(CCCc1ccccc1)N2CCC[C@H]2C(=O)N3CCC[C@H]3C#N
• InChI: 1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
• InChI Key: SPXFAUXQZWJGCJ-ROUUACIJSA-N

詳細

アプリケーション

KYP-2047 may be used in prolyl endopeptidase-mediated cell signaling studies.

生物化学的／生理学的作用

KYP-2047 clears the α-synuclein aggregates induced by oxidative stress in the neuronal cells. α-synuclein is the main component of Lewy bodies in Parkinson′s disease that cause neuronal cell death and dementia.

KYP-2047 is a very potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = .023nM (porcine). KYP-2047 has been found to be neuroprotective against glutamate and oxygen, glucose deprivation in vitro. It has also been used to inhibit the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.

特徴および利点

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H319
• 注意書き: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable