SML0148

イミダプリル 塩酸塩

≥98% (HPLC)

• 別名: (4S)-3-[(2S)-2-[[(1S)-1-(エトキシカルボニル)-3-フェニルプロピル]アミノ]-1-オキソプロピル]-1-メチル-2-オキソ-4-イミダゾリジンカルボン酸 塩酸塩, Novaloc, TA 6366, Tanapril
• 実験式（ヒル表記法）: C₂₀H₂₇N₃O₆ · HCl
• CAS番号: 89396-94-1
• 分子量: 441.91
• MDL番号: MFCD00923828
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825196
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 光学活性: [α]/D -50 to -70° in ethanol (c=0.5)
• 色: white to tan
• 溶解性: H₂O: ≥5 mg/mL
• オーガナイザー: Trinity Pharma Solutions
• 保管温度: −20°C
• SMILES記法: Cl.CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2[C@@H](CN(C)C2=O)C(O)=O
• InChI: 1S/C20H27N3O6.ClH/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28;/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26);1H/t13-,15-,16-;/m0./s1
• InChI Key: LSLQGMMMRMDXHN-GEUPQXMHSA-N

詳細

詳細

Imidapril comprises large acyl moiety and is hydrolyzed by carboxylesterase (CES) 1.

アプリケーション

Imidapril hydrochloride may be used to test its effect on pharyngeal and laryngeal muscle to treat impaired swallowing.

Imidapril hydrochloride was used as a standard in bioequivalence test by LC/MS method.

生物化学的／生理学的作用

アンジオテンシン変換酵素(ACE)阻害剤

イミダプリルは、強力なアンジオテンシン変換酵素阻害剤であり、降圧薬です。

Imidapril hydrochloride is a long-acting inhibitor of angiotensin converting enzyme used in the treatment of hypertension, congestive heart failure and diabetic nephropathy. It restores decreased airway sensation and bladder sensation in patients with multiple sclerosis.

特徴および利点

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Trinity Pharma Solutions. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable