SCP0084

カスパーゼ3基質

≥95% (HPLC), lyophilized

• 実験式（ヒル表記法）: C₃₁H₃₉N₅O₁₂
• 分子量: 673.67
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• 製品名: カスパーゼ3基質,
• アッセイ: ≥95% (HPLC)
• フォーム: lyophilized
• 組成: Peptide Content, ≥80%
• 保管条件: protect from light
• 保管温度: −20°C

詳細

Amino Acid Sequence

Ac-Asp-Glu-Val-Asp-4M2NA

詳細

Caspase 3 belongs to the family of cysteinyl proteases, which regulate apoptosis. It is encoded by CASP-3 gene. Caspase 3 is important for normal brain development. Caspase 3 is involved in growth stimulation of surviving tumor cells. It is associated with neuronal apoptosis in Alzheimer′s disease.

アプリケーション

Caspase 3 Substrate has been used to determine caspase activity in esophageal squamous cell carcinoma EC109 cell line.

Caspase 3, a cysteine protease activator of caspase 6 and caspase 7, metabolizes amyloid-β 4A precursor protein. Caspase 3 may be detected using a variety of chromogenic and fluorogenic peptide substrates built around the DxxD (asp-x-x-asp) sequences DMQD and DEVD such as Ac-DMQD-pNa (Acetyl-Asp-Met-Gln-Asp-p- nitroanalide), chromogenic; Ac-DMQD-AMC (Acetyl-Asp-Met-Gln-Asp- amino-4-methylcoumarin), fluorogenic and Ac-DEVD-4M2Na.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable