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Merck
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安全性情報

SBR00066

Sigma-Aldrich

Amikacin Ready Made Solution

25 mg/mL in water

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About This Item

CAS番号:
149022-22-0
UNSPSCコード:
51281632
NACRES:
NA.76

形状

liquid

品質水準

200

比活性

Antibacterial

濃度

25 mg/mL in water

抗生物質活性スペクトル

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

作用機序

protein synthesis | interferes

保管温度

2-8°C

SMILES記法

O=C([C@@H](O)CCN)N[C@H]1[C@H](O[C@@H]2[C@H](O)[C@@H](N)[C@H](O)[C@@H](CO)O2)[C@@H](O)[C@H](O[C@@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CN)O3)[C@@H](N)C1.O=S(O)(O)=O.[F,Cl,Br,I]

InChI

1S/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1

InChI Key

HIBICIOPDUTNRR-XTHCGPPUSA-N

詳細

Amikacin is semisynthetic aminoglycoside antibiotic derived from kanamycin A. Amikacin has broad spectrum activity against serious gram-negative bacilli drug resistant infections and also mycobacteria type infections. Amikacin binds to 30S bacterial ribosomal subunit causing a change of conformation, thus disrupting mRNA’s interaction with tRNA and hampering bacterial growth. Amikacin also showed potency against some gram-positive bacteria like methicillin-resistant Staphylococcus aureus (MRSA). Amikacin is extensively used for multidrug resistant tuberculosis treatment with 1ug/mL MIC value against Mycobacterium tuberculosis. Additionally, Amikacin MIC studies of gram negative and gram positive bacteria showed MIC distribution range of 0.094-48µg/ml. Several other studies showed that Amikacin has a synergistic effect combined with β-lactams against methicillin-resistant Staphylococcus spp. strains and Pseudomonas aeruginosa. Amikacin is additionally used for wound healing assays at concentration of 250 µg/mL.

その他情報

The suggested concentration of Amikacin for assays is 0.094-250 µg/mL therefore, it is recommended to dilute the ready made solution 1:100-266,000. Amikacin:Sulfate ratio 1:1.8

ピクトグラム

Exclamation mark
GHS07

シグナルワード

Warning

危険有害性情報

H317

危険有害性の分類

Skin Sens. 1

保管分類コード

12 - Non Combustible Liquids

WGK

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

SBR00066-10ML:
SBR00066-BULK:
SBR00066-VAR:

試験成績書（COA）

製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

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Etinosa O Igbinosa et al.
TheScientificWorldJournal, 2012, 308034-308034 (2012-05-26)
Pseudomonas aeruginosa is an opportunistic pathogen in environmental waters with a high prevalence of multidrug resistance. In this study the synergistic efficacy of synergy antibiotic combinations in multidrug-resistant P. aeruginosa strains isolated from an abattoir effluent was investigated. Water samples
N Düzgüneş et al.
Antimicrobial agents and chemotherapy, 32(9), 1404-1411 (1988-09-01)
We examined the therapeutic effects of free and liposome-encapsulated amikacin on Mycobacterium avium-M. intracellulare complex infection by using the beige-mouse model of the disease. In the first series of studies, intravenous administration of four weekly doses of 5 mg of
S Leitzke et al.
Antimicrobial agents and chemotherapy, 42(2), 459-461 (1998-04-04)
The potential of liposome-encapsulated antibiotics for prolonging drug application intervals was investigated by using a murine model of chronic lethal Mycobacterium avium infection. Liposomal encapsulation of amikacin, but not of ciprofloxacin, resulted in high and sustained drug levels in infected
Yun-Hsin Wang et al.
Toxics, 8(4) (2020-11-26)
(1) Background: Amikacin is an aminoglycoside antibiotic used for treating gram-negative bacterial infections in cancer patients. In this study, our aims are to investigate the migratory inhibition effects of amikacin in human MDA-MB-231 cells. (2) Methods: We used a wound-healing
Henri Sueke et al.
Investigative ophthalmology & visual science, 51(5), 2519-2524 (2009-12-19)
To determine the minimum inhibitory concentrations (MICs) of 12 antimicrobials in current ophthalmic use and 4 potentially new alternatives against isolates from bacterial keratitis. Bacteria were collected from cases of bacterial keratitis in six centers in the United Kingdom between
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