SBR00011

Clarithromycin, Ready Made Solution

50 mg/mL in DMSO

• 別名: 6-O-methyl erythromycin
• 実験式（ヒル表記法）: C₃₈H₆₉NO₁₃
• CAS番号: 81103-11-9
• 分子量: 747.95
• MDL番号: MFCD00865140
• UNSPSCコード: 51102829
• PubChem Substance ID: 329824644
• NACRES: NA.85

特性

• 詳細: Ready Made Solution
• 品質水準: 200
• フォーム: liquid
• 保管条件: dry media (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)
• 濃度: 50 mg/mL in DMSO
• 色: colorless to faint yellow
• 抗生物質活性スペクトル: Gram-positive bacteria
• 作用機序: protein synthesis | interferes
• 保管温度: −20°C
• InChI: 1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
• InChI Key: AGOYDEPGAOXOCK-KCBOHYOISA-N

詳細

詳細

Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions.

アプリケーション

Clarithromycin may be used for-

• the study of the effects of clarithromycin on rate-dependent changes in QT, T_p-e and proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations
• the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays
• the study of the synergism of NAB741 with clarithromycin in microtiter plates.

生物化学的／生理学的作用

Macrolides, such as clarithromycin, prevent protein synthesis in bacteria, by binding to 50S ribosomal subunit. It also binds to other ribosomal proteins, and prevents the translocation of pepti-dyl-tRNA. In patients with refractory asthma, it is capable of regulating the levels of interleukin-8 (IL-8), and neutrophil accumulation and activation in lungs. Thus, it might be used as an additional therapy in asthma to reduce noneosinophilic airway inflammation.

包装

2ML

保管および安定性

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.

その他情報

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 188.6 °F
• 引火点(℃): 87 °C