SBR00057

Retapamulin

≥98% (HPLC)

• 実験式（ヒル表記法）: C₃₀H₄₇NO₄S
• CAS番号: 224452-66-8
• 分子量: 517.76
• MDL番号: MFCD11045316
• UNSPSCコード: 51284706
• NACRES: NA.76

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 抗生物質活性スペクトル: Gram-positive bacteria
• 作用機序: protein synthesis | interferes
• 保管温度: −20°C
• SMILES記法: S(C4C[C@@H]5N([C@@H](CC5)C4)C)CC(=O)O[C@H]1[C@]2([C@H]3[C@@]([C@H]([C@@H]([C@](C1)(C)C=C)O)C)(CC[C@H]2C)CCC3=O)C
• InChI: 1S/C30H47NO4S/c1-7-28(4)16-24(35-25(33)17-36-22-14-20-8-9-21(15-22)31(20)6)29(5)18(2)10-12-30(19(3)27(28)34)13-11-23(32)26(29)30/h7,18-22,24,26-27,34H,1,8-17H2,2-6H3/t18-,19+,20-,21+,22?,24-,26+,27+,28-,29+,30+/m1/s1
• InChI Key: STZYTFJPGGDRJD-FJJJPKKESA-N

詳細

詳細

Retapamulin (RET) is a semi-synthetic antibiotic ointment, and pleuromutilin derivative compound. The primary structural difference between pleuromutilin and retapamulin is in the C-14 side chain.

生物化学的／生理学的作用

Retapamulin is a potent antibacterial agent against Gram-positive bacteria, especially against Staphylococcus aureus and S. pyogenes. It displays synergistic effects against Enterococcus faecalis in combination with streptogramin (MLS). RET initiates ribosomal arrests at the start codon and enables genes to use alternative translational sites in E. coli.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable