SAB4700332

Monoclonal Anti-CD54-FITC antibody produced in mouse

clone 1H4, purified immunoglobulin, buffered aqueous solution

• 別名: 抗ICAM1抗体
• UNSPSCコード: 12352203
• NACRES: NA.44

特性

• 由来生物: mouse
• 結合体: FITC conjugate
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 1H4, monoclonal
• 形状: buffered aqueous solution
• 化学種の反応性: human
• テクニック: flow cytometry: suitable
• アイソタイプ: IgG2b
• NCBIアクセッション番号: NM_000201.2
• UniProtアクセッション番号: P05362
• 輸送温度: wet ice
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ICAM1(3383)

詳細

詳細

CD54 (cluster of differentiation 54), also known as ICAM1 (intercellular adhesion molecule 1) was initially identified as a ligand for the β2 integrin lymphocyte function-associated antigen (LFA)-1. It is a glycoprotein with a 90,000-110,000 molecular weight and shows wide range of tissue expression, including tissue macrophages and dendritic cells. It also shows expression on non-hematopoietic cells such as vascular endothelial cells, epithelial cells of thymus and mucosa and dermal fibroblasts. It is a member of the ICAM family, which also includes ICAM-2, -3, -4 and -5.

The antibody 1H4 reacts with CD54 (ICAM-1), a 85-110 kDa type I transmembrane glycoprotein (receptor for rhinovirus) expressed on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells; the expression of CD54 is upregulated by activation.

免疫原

Raji cells and spleen cells fused with NS1 cells

アプリケーション

試薬は、100 μL全血または1e6細胞懸濁液につき20 μLの試薬を用いたヒト血液細胞のフローサイトメトリー解析用にデザインされています。バイアル（2 mL）の内容量は100回分です。

生物化学的／生理学的作用

The expression of CD54 (cluster of differentiation 54)/ICAM1 (intercellular adhesion molecule 1) is strongly increased by interleukin-1 (IL-1) and interferon (IFN)-γ. It is expressed on lymphoid cells where it is required for phorbol ester-induced aggregation. It participates in lymphocyte function-associated antigen 1 (LFA-1)-dependent NK cell stimulation through its attachment to actin cytoskeleton through α-actinin or ezrin. It also acts as the receptor for rhinovirus, a common cold virus and Plasmodium falciparum. Soluble ICAM-1 levels are elevated in pregnant women with gestational diabetes mellitus (GDM), which is an outcome of endothelial cell activation and dysfunction. Meta-analysis of case-control studies show that rs1799969 polymorphism in ICAM-1 gene is linked with increased susceptibility to cancer.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

PBS（15 mM アジ化ナトリウム、安定化剤として0.2％ハイグレード プロテアーゼフリーBSA含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable