SAB4300077

Anti-phospho-TP53 (pSer³⁷) antibody produced in rabbit

affinity isolated antibody

• 別名: 抗LFS1抗体 ウサギ宿主抗体, 抗TRP53抗体 ウサギ宿主抗体, 抗p53抗体 ウサギ宿主抗体
• MDL番号: MFCD00164709
• UNSPSCコード: 12352203
• NACRES: NA.43

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: ~53 kDa
• 交差性: human
• 濃度: 1 mg/mL
• テクニック: indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• アイソタイプ: IgG
• 免疫原配列: (L-P-SP-Q-A)
• NCBIアクセッション番号: NP_000537.3
• UniProtアクセッション番号: P04637
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pSer37)
• 遺伝子情報: human ... TP53(7157)

詳細

免疫原

Peptide sequence around phosphorylation site of serine 37 (L-P-S(p)-Q-A), according to the protein TP53.

特徴および利点

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ターゲットの説明

p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes

物理的形状

PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable