おすすめの製品
由来生物
mouse
品質水準
抗体製品の状態
purified from hybridoma cell culture
抗体製品タイプ
primary antibodies
クローン
HP-6014, monoclonal
フォーム
buffered aqueous solution
交差性
human
濃度
~1.0 mg/mL
テクニック
immunofluorescence: suitable
indirect ELISA: 0.07-0.15 μg/mL using 1 μg/mL Human IgG2 myeloma for coating
アイソタイプ
IgG1
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
詳細
Anti-Human IgG2 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the HP-6014 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified human IgG2 myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads. Human IgG consist of four subclasses (1-4) that can be recognized by antigenic differences in their heavy chains. They constitute approximately 65, 30, 5, and 4% of the total IgG, respectively.
免疫原
Purified human IgG2 myeloma protein
アプリケーション
Anti-Human IgG2 antibody, Mouse monoclonal may be used in immunological techniques, including enzyme linked immunosorbent assay (ELISA), immunofluorescence, hemagglutination (HA) and hemagglutination inhibition.
生物化学的／生理学的作用
Lipopolysaccharides stimulate an IgG2 response in peripheral blood leukocytes (PBL) and an IgG1 response in the spleen. Only IgG1 and IgG3 are capable of adherence to mononuclear phagocytes while IgG2 and IgG4 autoantibodies are much less efficient. The amount of the different IgG subclasses present in the blood shows variation with age. For example, IgG1 and IgG3 reach normal adult levels by 5-7 years of age while IgG2 and IgG4 levels raise more slowly, reaching adult levels at about 10 years of age. Serum IgG subclass deficiencies have been recorded for different patient groups. For example, IgG2 and IgG4 deficiency is found in patients of ataxia telangiectasia. Low IgG2 levels were found in patients with Systemic lupus erythematosus (SLE) and juvenile diabetes mellitus.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4200783-BULK:
SAB4200783-VAR:
SAB4200783-100UL:
最新バージョンのいずれかを選択してください：
Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood
Blanco E, et al.
The Journal of Allergy and Clinical Immunology, 141(6), 2208-2219 (2018)
Immunoglobulin G; structure and functional implications of different subclass modifications in initiation and resolution of allergy
Scott-Taylor TH, et al.
Immunity, inflammation and disease, 6, 13-33 (2018)
V A Oxelius et al.
Clinical and experimental immunology, 99(2), 211-215 (1995-02-01)
IgA deficiency (IgAD) is the most common immunodeficiency, characterized by an arrest in B cell differentiation. It has a sporadic occurrence or variable inheritance pattern, and is also linked to the HLA genes. IgA deficiency is sometimes associated with IgG
Effect of anti-epileptic drugs on serum level of IgG subclasses
Ashrafi MR, et al.
Iranian journal of pediatrics, 20(3), 269-269 (2010)
Immunodeficiency and infections in ataxia-telangiectasia
Nowak-Wegrzyn A, et al.
The Journal of Pediatrics, 144(4), 505-511 (2004)
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