I7385

モノクロナール抗ヒトIgG4 マウス宿主抗体

clone HP-6025, ascites fluid

• 別名: モノクロナール抗ヒトIgG4
• UNSPSCコード: 12352203
• NACRES: NA.46

特性

• 由来生物: mouse
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: ascites fluid
• 抗体製品タイプ: secondary antibodies
• クローン: HP-6025, monoclonal
• 含みます: 15 mM sodium azide
• テクニック: immunofluorescence: suitable; indirect ELISA: 1:5,000
• アイソタイプ: IgG1
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified

詳細

詳細

IgG4 (Immunoglobulin G4) is produced by T helper 2 cytokines. Unlike other immunoglobulin G is rare and constitutes to only 3-4 percent of the total IgG in the serum.

特異性

モノクロナール抗ヒトIgG4 は IgG4のサブクラスに特異性を示し、ELISAが使用するIgG1、 IgG2、IgG3とは反応しません。

アプリケーション

IUIS/WHO2が行った研究では、最も広範に適用できるIgG4特異性モノクロナール抗体としてこのモノクロナール抗体を選定しています。 次のような各種の免疫アッセイでは、IgG4サブクラスの識別と同定のためにモノクロナール抗ヒトIgG4を使用することがあります：ELISA、インプリント免疫固定(IIF)、免疫蛍光アッセイ(IFMA)、赤血球凝集(HA)、赤血球凝集阻害(HAI)、 粒子計数免疫アッセイ(PACIA)、および細胞質IgG検出。

Monoclonal Anti-HuIgG4 man antibody produced in mouse has been used in ELISA and immunofluorescence.

生物化学的／生理学的作用

IgG4 (Immunoglobulin G4) antibody has reduced affinity for C1q (first component of complement q) and hence its anti-inflammatory activity differing from that of the other IgG subclasses. IgG4 antibodies are known to actively interchange Fab arms with another molecule, resulting in recombined antibodies with two different binding specificities. This exchange is considered as an important biological mechanism that contributes to its anti-inflammatory activity. IgG4 antibodies are normally noninflammatory, but autoreactive IgG4 antibodies are known to be associated with Immunoglobulin G4 (IgG4)-related disease (IgG4-RD), characterized by infiltrating lymphoplasmacytic cells and elevated serum IgG4. Increased levels of IgG4 is observed in atopic dermatitis, parasitic diseases, pemphigus vulgaris and pemphigus foliaceus.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable