SAB4200403

Anti-EXOSC8 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 別名: Anit-CIP3, Anit-Exosome component 8,p9, Anti-EAP2, Anti-OIP2, Anti-Opa interacting protein 2, Anti-RP11-421P11.3, Anti-RRP43, Anti-Ribosomal RNA-processing protein 43, Anti-Rrp43p, AntiCBP-interacting protein 3
• UNSPSCコード: 12352203

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~34 kDa
• 交差性: mouse, human, rat
• 濃度: ~1.0 mg/mL
• テクニック: immunoprecipitation (IP): 1-2 μg using human HEK-293T cell lysate; western blot: 1-2 μg/mL using whole extracts of mouse A20 and rat PC12 cells
• UniProtアクセッション番号: Q96B26
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: bovine ... EXOSC8(532080) ; dog ... EXOSC8(477300) ; human ... EXOSC8(11340) ; mouse ... Exosc8(69639)

詳細

詳細

Exosome component 8 (EXOSC8) or RRP43, a 3′ to 5′ exoribonuclease, is a component of the eukaryotic exosome (a 400 kDa complex). EXOSC8 is part of the hexameric ring, along with EXOSC4-7 and EXOSC9. This is further capped by three RNA binding subunits (EXOSC1-EXOSC3). EXOSC8 gene is mapped to human chromosome 13q13.3 and is localized in nucleus and cytoplasm.

特異性

Anti-EXOSC8 (N-terminal) recognizes human, mouse and rat EXOSC8.

免疫原

peptide corresponding to the N-terminal region of human EXOSC8, conjugated to KLH.

アプリケーション

Anti-EXOSC8 (N-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.

生物化学的／生理学的作用

Exosome component 8 (EXOSC8) interacts with AU-rich element (ARE)-containing mRNAs and its deficiency halts growth in yeast. Mutations in the EXOSC8 gene is implicated in Ponto-cerebellar hypoplasia.

物理的形状

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

保管および安定性

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免責事項

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable