SAB2501506

Anti-ZCCHC11 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• 別名: Anti-KIAA0191, Anti-bHLHa22, CCHC domain containing 11, PAP associated domain containing 3, Zinc finger
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: ELISA (i); IF; IHC
• クローン: polyclonal
• 化学種の反応性: canine, bovine, human, rat, mouse
• citations: 4
• テクニック: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable

特性

• 由来生物: goat
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 化学種の反応性: canine, bovine, human, rat, mouse
• テクニック: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable
• UniProtアクセッション番号: Q5TAX3
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ZCCHC11(23318)

詳細

詳細

Zinc finger CCHC-type containing 11 (ZCCHC11) is a 3′ terminal uridylyl transferase. It possesses multiple domains and has a molecular weight of about 185kDa. A fragment of the protein contains a TRF4 domain, a nucleotidyl transferase domain (NTD), two PAP-associated domains and three zinc finger domains. The ZCCHC11 gene is localized on human chromosome 1p32.3.

免疫原

Peptide with sequence RERCPHPPRGNVSE, from the C-terminal region of the protein sequence according to NP_001009881.1; NP_056084.1; NP_001009882.1

生物化学的／生理学的作用

Zinc finger CCHC-type containing 11 (ZCCHC11) has a role in the RNA-binding protein Lin28 blockade of let-7 microRNA biogenesis. It is recruited by Lin28 to pre-let-7 (let-7 precursors), where it catalyzes the addition of an oligo (U)-tail.The protein is crucial for poly (A) tail length maintenance. ZCCHC11 also has a role in regulating the stability of transcripts for interleukin-6 and other cytokines.

特徴および利点

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物理的形状

20mM Tris（pH 7.3）、150mM NaCl、0.02％ アジ化ナトリウム、0.5％ ウシ血清アルブミン含有）を含む溶液中に0.5 mg/mLの濃度で提供されます。

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable