S5069

抗スーパーオキシドジスムターゼ (MnSOD) (DD-17) ウサギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• 別名: 抗IPO-B抗体, 抗MNSOD抗体, 抗Mn-SOD抗体, 抗SOD2抗体, 抗インドフェノールオキシダーゼB抗体, 抗スーパーオキシドジスムターゼ2抗体, 抗マンガンスーパーオキシドジスムターゼ2抗体, 抗マンガン依存性SOD抗体, 抗ミトコンドリアSOD抗体
• MDL番号: MFCD06798545
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~24 kDa
• 化学種の反応性: rat, human
• 強化検証: independent; Learn more about Antibody Enhanced Validation
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10-20 μg/mL using biotin/ExtraAvidin^®-peroxidase staining of human heart sections; indirect immunofluorescence: 10-20 μg/mL using methanol-acetone-fixed rat NRK cells; western blot: 1-2 μg/mL using human HeLa mitochondria extract and a chemiluminescent detection reagent; western blot: 2-4 μg/mL using whole extract of rat brain and a chemiluminescent detection reagent
• UniProtアクセッション番号: P04179
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... SOD2(6648) ; rat ... Sod2(24787)

詳細

詳細

Superoxide Dismutase (SOD) is a metalloprotein enzyme. It is widely distributed in the animal and plant kingdoms. The three common mammalian endogenous isozymes are the homodimeric copper-zinc SOD (Cu,ZnSOD, SOD1) found primarily in the cytosol, the homotetrameric glycosylated copper-zinc SOD, extracellular SOD (EC-SOD, SOD3), and the homotetrameric mitochondrial manganese SOD (MnSOD, SOD2). All three are nuclear-encoded. MnSOD is composed of four subunits, each containing one Mn²⁺.

免疫原

ヒトス-パ-オキシドジスムタ-ゼ(MnSOD)のアミノ酸183~199(N末端システイン付加)に相当する合成ペプチドのKLH結合体。相当する配列は多くの真核生物で保存されています。

アプリケーション

The antibody may be detected by various immunochemical techniques including immunoblotting, co-immunoprecipitation assay (co-IP), immunoprecipitation, indirect immunofluorescence and immunohistochemistry.

生物化学的／生理学的作用

Superoxide Dismutase (SOD) catalyzes the dismutation of the cytotoxic superoxide radical (O² -) to molecular oxygen and hydrogen peroxide. Manganese SOD (MnSOD) has been proposed to function as a tumor suppressor by modulating the activity of redox-sensitive transcription factors and specific signal mediators. MnSOD is involved in detoxification.

物理的形状

PBS溶液(pH 7.4, 1%BSA, 15mMアジ化ナトリウム含有)。

法的情報

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable