S4322

抗Sirt6 (N-末端) ウサギ宿主抗体

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• 別名: 抗NAD依存性脱アセチル化酵素サーチュイン6抗体, 抗SIR2L6抗体, 抗SIR2様タンパク質6抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~40 kDa
• 化学種の反応性: rat (predicted), mouse, human
• 包装: antibody small pack of 25 μL
• 濃度: ~1 mg/mL
• テクニック: western blot: 2-4 μg/mL using whole extracts of human 293 cells transfected with Sirt6; western blot: 2-4 μg/mL using whole extracts of mouse 3T3 cells
• UniProtアクセッション番号: Q8N6T7
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... SIRT6(51548) ; rat ... Sirt6(299638)

詳細

詳細

Sirtuin 6 (Sirt6) is a nuclear and chromatin-associated protein that belongs to the mammalian Sir2 gene family. It is broadly expressed with the highest levels in muscle, brain and heart.

特異性

Anti-Sirt6 (N-terminal) recognizes human and mouse Sirt6. The detection of the Sirt6 band by immunoblotting is specifically inhibited with the immunizing peptide.

免疫原

ヒトSirt6のアミノ酸19~33に相当する合成ペプチド (C末端システイン付加)。この配列はマウスと同一であり、ラットとは1アミノ酸異なります。

アプリケーション

Anti-Sirt6 (N-terminal) antibody produced in rabbit has been used in immunoblotting.

生物化学的／生理学的作用

Sirtuin 6 (Sirt6) plays a key role in DNA repair and maintenance of genomic stability in cells. Sirt6 is enzymatically inactive as a NAD⁺ -dependent protein deacetylase but displays auto-ADP-ribosyltransferase activity. Loss of Sirt6 leads to the development of an acute degenerative aging-like phenotype.

物理的形状

0.01M PBS溶液 (pH 7.4, 15mM アジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)