おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen ~40 kDa
化学種の反応性
human
濃度
~1 mg/mL
テクニック
indirect immunofluorescence: suitable
western blot: 0.5-1 μg/mL using whole extracts of human U87 cells
western blot: 2.5-5 μg/mL using human HeLa cells
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... SIRT6(51548)
詳細
Sirtuin 6 (Sirt6) is a nuclear, chromatin-associated protein. Sirt6 is a member of Sir2 gene family. It is broadly expressed with the highest levels in muscle, brain and heart.
免疫原
ヒトSirt6のアミノ酸330~348に相当する合成ペプチド。
アプリケーション
Anti-Sirt6 (C-terminal) antibody has been used in
- immunoblotting
- immunofluorescence
- western blotting
- immunohistochemistry
生物化学的／生理学的作用
Sirtuin 6 (Sirt6) plays a key role in DNA repair and maintenance of genomic stability in cells. Sirt6 is enzymatically inactive as a NAD+ -dependent protein deacetylase but displays auto-ADP-ribosyltransferase activity. Loss of Sirt6 leads to the development of an acute degenerative aging-like phenotype.
物理的形状
0.01 M PBS溶液 (pH 7.4, 15 mM アジ化ナトリウム含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
S4197-VAR:
IXO14198:
S4197-BULK:
S4197-25UL:
S4197-200UL:
Sirtuin 6 expression and inflammatory activity in diabetic atherosclerotic plaques: effects of incretin treatment
Balestrieri M L, et al.
Diabetes, 64(4), 1395-1406 (2015)
Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
Mao Z, et al.
Proceedings of the National Academy of Sciences of the USA, 109(29), 11800-11805 (2012)
Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells
Lappas, Martha
Mediators of Inflammation, 2012 (2012)
Longsen Han et al.
Scientific reports, 5, 15366-15366 (2015-10-21)
Sirt6, a member of the sirtuin family of NAD-dependent protein deacetylases, has been implicated in multiple biological processes. However, the roles of Sirt6 in meiosis have not been addressed. In the present study, by employing knockdown analysis in mouse oocytes
Juan Ge et al.
Aging, 11(7), 1965-1976 (2019-03-31)
It has been well recognized that oocyte quality declines in aging animals. However, to date, the underlying mechanism remains to be explored. In the present study, we report that oocytes and embryos from aged mice (42-45 weeks old) display the
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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