PZ0221

PF-06439015 methanesulfonate salt

≥98% (HPLC)

• 別名: 2R-(5-{6-Amino-5-[1R-(5-fluoro-2-[1,2,3]triazol-2-yl-phenyl)-ethoxy]-pyridin-3-yl}-4-methyl-thiazol-2-yl)-propane-1,2-diol methanesulfonate, PF-06439015 mesylate, PF-06439015 methanesulfonate
• 実験式（ヒル表記法）: C₂₂H₂₃FN₆O₃S · CH₃SO₃H
• CAS番号: 1565822-20-9
• 分子量: 566.63
• MDL番号: MFCD27978372
• UNSPSCコード: 12352200
• PubChem Substance ID: 329823778
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: H₂O: 15 mg/mL, clear
• 保管温度: room temp
• SMILES記法: OC[C@](O)(C)C(S1)=NC(C)=C1C2=CN=C(N)C(O[C@H](C)C3=C(N4N=CC=N4)C=CC(F)=C3)=C2.CS(O)(=O)=O
• InChI: 1S/C22H23FN6O3S.CH4O3S/c1-12-19(33-21(28-12)22(3,31)11-30)14-8-18(20(24)25-10-14)32-13(2)16-9-15(23)4-5-17(16)29-26-6-7-27-29;1-5(2,3)4/h4-10,13,30-31H,11H2,1-3H3,(H2,24,25);1H3,(H,2,3,4)/t13-,22-;/m1./s1
• InChI Key: CVPQOLHPYNCJHK-RSUIGRPMSA-N

詳細

生物化学的／生理学的作用

PF-06439015 is a potent and selective inihibitor that overcomes clinical ALK (receptor tyrosine kinase anaplastic lymphoma kinase) mutations resistant to Crizotinib.

PF-06439015 is a potent and selective inihibitor that overcomes clinical ALK (receptor tyrosine kinase anaplastic lymphoma kinase) mutations resistant to Crizotinib. PF-06439015 is potent across a broad panel of ALK mutant cell lines with an IC₅₀ of 6.6 nM for tumor growth inhibition in a crizotinib-resistant cell line (H3122-L1196M).

特徴および利点

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安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable