P7854

抗プレセニリン-1(S182)抗体 ウサギ宿主抗体

IgG fraction of antiserum, buffered aqueous solution

• 別名: Anti-ACNINV3, Anti-AD3, Anti-FAD, Anti-PS-1, Anti-PS1, Anti-S182
• MDL番号: MFCD02097229
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: IgG fraction of antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 化学種の反応性: mouse, human, Xenopus, rat
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using methacarn-fixed, formic acid-treated sections of Alzheimer′s Disease (AD) brain; microarray: suitable; western blot: 1:10,000 using whole cell extract of PC12 rat adrenal pheochromocytoma cell line
• UniProtアクセッション番号: P49768
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PSEN1(5663) ; mouse ... Psen1(19164) ; rat ... Psen1(29192)

詳細

詳細

Presenilin 1& 2 (PS1 and PS2) are highly homologous proteins (approx. 43-52 kD) with eight transmembrane domains. In the brain, PS1 and PS2 are expressed primarily in neurons and localized mainly in cell bodies, axons and dendrites. In non-neuronal cells, PS1 and PS2 are localized to the nuclear membrane, endoplasmic reticulum and Golgi. Presenilin 1 is located on chromosome 14.

特異性

免疫原はプレセニリン2には認められない、プレセニリン1特異的配列で、マウス, ラット, Xenopusで一致しています。イムノブロッティングにおいて、抗体はプレセニリン1(PS1, S182)およびPS1分解産物と反応します。

免疫原

ヒトプレセニリン-1のC末端側アミノ酸450-467 (N末端リジン付加)に相当する合成ペプチドのKLH結合体。

アプリケーション

Anti-Presenilin-1 (S182) antibody produced in rabbit has been used in:

• immunostaining
• immunofluorescence detection
• immunohistochemistry
• immunoblotting

生物化学的／生理学的作用

The biological functions of the presenilin′s are yet unknown, but they are thought to be involved in protein trafficking. Mutations in the presenilin 1 (PS1) gene (>30 known pathogenic mutations) have been found in about half of the early-onset familial Alzheimer′s disease (FAD), while only two pathogenic mutations have been found in PS2.

物理的形状

0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids