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Merck
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資料

安全性情報

P6249

Sigma-Aldrich

p53 ヒト

recombinant, expressed in E. coli, buffered aqueous glycerol solution

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About This Item

UNSPSCコード:
12352202
NACRES:
NA.25

由来生物

human

品質水準

200

リコンビナント

expressed in E. coli

アッセイ

≥90% (SDS-PAGE)

形状

buffered aqueous glycerol solution

UniProtアクセッション番号

P04637

アプリケーション

genomic analysis

輸送温度

wet ice

保管温度

−20°C

遺伝子情報

human ... TP53(7157)

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詳細

p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′ terminal transactivation domain.

アプリケーション

p53の翻訳後修飾やタンパク質間相互作用に関する研究に適しています。

生物化学的／生理学的作用

p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.

物性

GSTタグ付加完全長ヒトp53

保管分類コード

10 - Combustible liquids

WGK

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

P6249-VAR:
P6249-50UG-PW:
P6249-50UG:
P6249-BULK:

試験成績書（COA）

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Slide 1 of 4

1 of 4

Human p53 ELISA Kit for serum, plasma, cell culture supernatant and urine

Sigma-Aldrich

RAB0500

Human p53 ELISA Kit

MDM2 ヒト recombinant, expressed in E. coli, ≥80% (SDS-PAGE), buffered aqueous solution

Sigma-Aldrich

SRP2095

MDM2 ヒト

ANTI-P53 (S15) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

SAB1306667

ANTI-P53 (S15) antibody produced in rabbit

モノクロナール抗p53 マウス宿主抗体 clone PAb1801, purified from hybridoma cell culture

Sigma-Aldrich

P6749

モノクロナール抗p53 マウス宿主抗体

Dania Alarcon-Vargas et al.
Carcinogenesis, 23(4), 541-547 (2002-04-19)
The p53-Mdm2 paradigm represents the best-studied relationship between a tumor suppressor gene which functions as a transcription factor and an oncogene, which functions primarily as an E3 protein ligase. The intimate relationship between these two partners has expanded to include
Se Kyung Lee et al.
PloS one, 10(8), e0124658-e0124658 (2015-08-05)
Overexpression of p53 is the most frequent genetic alteration in breast cancer. Recently, many studies have shown that the expression of mutant p53 differs for each subtype of breast cancer and is associated with different prognoses. In this study, we
Alejandra Ward et al.
BMC cancer, 11, 71-71 (2011-02-18)
Hepatocellular carcinoma (HCC), one of the most common cancers world-wide occurs twice as often in men compared to women. Predisposing conditions such as alcoholism, chronic viral hepatitis, aflatoxin B1 ingestion, and cirrhosis all contribute to the development of HCC. We
Brandon S Sheffield et al.
The American journal of surgical pathology, 39(7), 977-982 (2015-01-31)
A variety of immunohistochemical (IHC) stains have been proposed to mark either benign or malignant mesothelial proliferations. Loss of the p16 tumor suppressor (CDKN2A), through homozygous deletions of 9p21, is a good marker of mesotheliomas but lacks sensitivity. Recent reports
Cristina Muñoz-San Martín et al.
Analytical and bioanalytical chemistry, 412(24), 6177-6188 (2020-01-29)
Proteases are involved in cancer' taking part in immune (dis)regulation, malignant progression and tumour growth. Recently, it has been found that expression levels of one of the members of the serine protease family, trypsin, is upregulated in human cancer cells
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資料

Huntington's Disease

Huntington's disease (HD) is an autosomal dominant, late-onset neurodegenerative disorder characterized by a selective neuronal cell death in the cortex and striatum leading to cognitive dysfunction, motor impairment and behavioral changes.

Oncogenes and Tumor Suppressors Reprogram Metabolism

We present an article about how proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication.

Oncogenes and Tumor Suppressors Reprogram Metabolism

Sigma-Aldrich presents an article about how proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication.

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