P4904

β-アセチル-γ-O-ヘキサデシル-L-α-ホスファチジルコリン

≥98%

• 別名: 1-O-パルミチル-2-アセチル-sn-グリセロ-3-ホスホコリン 一水和物, 1-ヘキサデシル-2-アセチル-sn-グリセロ-3-ホスホコリン, 2-アセチル-1-ヘキサデシル-sn-グリセロ-3-ホスホコリン, 3-sn-ホスファチジルコリン, 1-ヘキサデシル-2-アセチル, PAF(C₁₆), 血小板活性化因子
• 実験式（ヒル表記法）: C₂₆H₅₄NO₇P · xH₂O
• CAS番号: 74389-68-7
• 分子量: 523.68 (anhydrous basis)
• Beilstein: 3574588
• MDL番号: MFCD00150679
• UNSPSCコード: 12352211
• PubChem Substance ID: 24898570
• NACRES: NA.77

特性

• アッセイ: ≥98%
• 形状: powder
• 保管温度: −20°C
• SMILES記法: O.CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O
• InChI: 1S/C26H54NO7P.H2O/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5;/h26H,6-24H2,1-5H3;1H2/t26-;/m1./s1
• InChI Key: HFMSDOHEENWULV-UFTMZEDQSA-N

詳細

アプリケーション

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine has been used:

• to study its effects on phagocytic activity and production of superoxide anion in equine alveolar macrophage and blood neutrophils
• to study its protective effects against cisplatin-induced cell death in a human melanoma cell line in vitro
• to determine its effects on cervical ripening and leukocyte infiltration in rat models

生物化学的／生理学的作用

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine or platelet-activating factor (PAF), is a phospholipid, and a pro-inflammatory lipid mediator. It acts as a ligand for G protein-coupled platelet-activating factor (PAF) receptors and participates in several biological processes such as airway constriction, hypotension, platelet activation, and increased vascular permeability. PAF is released by various cells such as platelets, neutrophils, endothelial cells, and monocytes/macrophages. The levels of PAF are low in the blood due to its rapid metabolism by PAF acetylhydrolase and low production.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)