P246

モノクロナール抗PSD95 マウス宿主抗体

clone 7E3-1B8, purified immunoglobulin, buffered aqueous solution

• 別名: Anti-MRD62, Anti-PSD95, Anti-SAP-90, Anti-SAP90
• MDL番号: MFCD01324382
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 7E3-1B8, monoclonal
• 形状: buffered aqueous solution
• 分子量: antigen 95 kDa
• 化学種の反応性: rat
• テクニック: immunofluorescence: 1:500; immunoprecipitation (IP): suitable; western blot: 1:2,000
• アイソタイプ: IgG2a
• UniProtアクセッション番号: P31016
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: rat ... Dlg4(29495)

詳細

詳細

DLG4 (discs large MAGUK scaffold protein 4) gene codes for the postsynaptic density-95 (PSD95) protein. Postsynaptic density 95 (PSD-95), a synaptic scaffolding protein is also a membrane-associated guanylate kinase (MAGUK) family protein. It has three PDZ domains on the N terminus followed by a Src homology 3 (SH3) domain and a guanylate kinase (GK) domain. This gene is located on human chromosome 17p13.1.

特異性

組み換え型および天然型PSD95のどちらとも反応します。ラット海馬細胞の免疫蛍光法において、シナプス部位のNMDA受容体の染色と一致し、提唱されている受容体クラスタリングにおける役割と一致する染色パタ-ンが認められます。冷メタノ-ルでの固定を推奨します。

免疫原

組み換え型ラットPSD95 (シナプス後膜肥厚95 kDa)。

アプリケーション

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunofluorescence (1 paper)
Western Blotting (1 paper)

生物化学的／生理学的作用

Postsynaptic density 95 (PSD-95) plays a major role in bidirectional synaptic plasticity, an important process, essential for learning and memory. It exhibits increased dynamics upon induction of plasticity.

物理的形状

PBS溶液 (0.05%アジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)