P0037

PP242 水和物

≥98% (HPLC), powder

• 別名: 2-(4-アミノ-1-イソプロピル-1H-ピラゾロ[3,4-d]ピリミジン-3-イル)-1H-インドール-5-オール
• 実験式（ヒル表記法）: C₁₆H₁₆N₆O · xH₂O
• CAS番号: 1173019-76-5
• 分子量: 308.34 (anhydrous basis)
• MDL番号: MFCD12828866
• UNSPSCコード: 12352200
• PubChem Substance ID: 329819988
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: off-white
• 溶解性: DMSO: >10 mg/mL
• 保管温度: 2-8°C
• SMILES記法: O.CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c4c(N)ncnc14
• InChI: 1S/C16H16N6O.H2O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12;/h3-8,20,23H,1-2H3,(H2,17,18,19);1H2
• InChI Key: FMDOLJSFPXFBIL-UHFFFAOYSA-N

詳細

アプリケーション

PP242 hydrate has been used:

• as a mammalian target of rapamycin (mTOR) inhibitor to study its effects on rat fibroblast mTOR complex 1 and 2 (mTORC1 & 2) signaling
• as an mTOR inhibitor to treat mouse embryonic fibroblasts (MEF) and cumulus cells (CCs) to study its effects on reactivation of embryonic nucleoli and ribosome biogenesis
• as a target of rapamycin (TOR) kinase inhibitor for the treatment of Arabidopsis to study its effects against Fusarium graminearum infection

生物化学的／生理学的作用

PP242は強力かつ選択的なmTORインヒビターです。PP242はmTORのATPドメインを標的とする初の選択的インヒビターです。

特徴および利点

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable