MTOXCE19A1

CypExpress^™ Aromatase

• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 由来生物: human
• リコンビナント: expressed in Pichia pastoris
• 形状: dry powder
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... CYP19A1(1588)

詳細

生物化学的／生理学的作用

Aromatase is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities

Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous.

特徴および利点

CypExpress 19A1 also know as Aromatase is a permeabilized and stabilized dried yeast powder preparation containing full length, unmodified, human CYP 19A1 and recombinant human NADPH oxidoreductase. Using proprietary processes, CypExpress are expressed in Pichia yeast. Following optimal expression, the cells are inactivated, permeabilized and dried to a fine powder. CypExpress retains the cellular mechanisms to provide the P450 enzymes with the energy and cofactors to continue to function for long experiments, and can generate larger amounts of metabolite than mammalian microsomes or other genetically engineered expression systems.It is designed for rapid screening of drug metabolites and for scaling up metabolite generation.

法的情報

CypExpress is a trademark of Oxford Biomedical Research

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1