おすすめの製品
由来生物
bovine muscle
品質水準
タイプ
Type X
アッセイ
3.0—25.0 mg protein/mL (biuret)
形状
ammonium sulfate suspension
比活性
≥600 units/mg protein
メーカー／製品名
Sigma-Aldrich
テクニック
activity assay: suitable
色
white
pH
7.5
アプリケーション
life science and biopharma
その他の活性
pyruvate kinase ≤0.01%
保管温度
2-8°C
遺伝子情報
cow ... LDHA(281274) , LDHB(281275)
詳細
Research Area: Cell Signaling
Lactate dehydrogenase (LDH) is a key enzyme in the anaerobic metabolic pathway and falls under the class of oxidoreductases. This enzyme is found in a wide range of organisms, including both plants and animals. It is widely distributed across all tissues. LDH is primarily a cytoplasmic enzyme, with particularly high concentrations in muscle, liver, and kidney tissues.
Lactate dehydrogenase (LDH) is a key enzyme in the anaerobic metabolic pathway and falls under the class of oxidoreductases. This enzyme is found in a wide range of organisms, including both plants and animals. It is widely distributed across all tissues. LDH is primarily a cytoplasmic enzyme, with particularly high concentrations in muscle, liver, and kidney tissues.
アプリケーション
L-Lactic Dehydrogenase from bovine muscle has been used in lactate assay to assess lactate tissue accumulation.
生物化学的／生理学的作用
Lactate dehydrogenase (LDH) plays a critical role as a checkpoint in gluconeogenesis and DNA metabolism. It plays a vital role in maintaining homeostasis during periods of low oxygen availability. As an oxidoreductase enzyme, lactate dehydrogenase catalyzes the reversible conversion of pyruvate to lactate using NADH. This enzyme is crucial for the anaerobic metabolism of glucose when oxygen is either absent or in short supply. LDH is the sole serum biomarker effective for evaluating metastatic melanomas.
また、他のL-2-hydroxymonocarboxylic acidの酸化を触媒します。
単位の定義
1ユニットは、pH 7.5、37°C、1分間で、1.0 μmolのピルビン酸をL-乳酸へと還元する酵素量です。
物理的形状
pH 6.0の2.4 M (NH}4)2SO4溶液への結晶性懸濁液
アナリシスノート
タンパク量はビウレット法で測定
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Resp. Sens. 1
保管分類コード
11 - Combustible Solids
WGK
WGK 1
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
L1378-75KU:
L1378-BULK:
L1378-37.5KU:
L1378-VAR:
L1378-15KU:
L1378-3KU:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
この製品を見ている人はこちらもチェック
Vasco Meneghini et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(14), 6047-6059 (2013-04-05)
Dysregulated hippocampal neurogenesis has been associated with neurodegenerative disorders, including Alzheimer's disease (AD), in which it may potentially represent an auto-reparatory mechanism that could counteract neuronal loss and cognitive impairment. We evaluated hippocampal neurogenesis in TgCRND8 mice and reported that
Sebastian-Jonas Saur et al.
Deutsche medizinische Wochenschrift (1946), 138(16), Seite 1-Seite30 (2013-04-24)
We report on the case of a young women presenting with macrohaematuria, petechiae and strong headaches. Laboratory showed a thrombotic microangiopathy with helmet cells, increased LDH levels (>600 U/l), and thrombocytopenia (<40,000/μl). Due to strong haemolytic activity and headache with
Wei Quan et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 33(1), 85-91 (2013-04-20)
To determine the cardioprotective effect of magnesium lithospermate B (MLB) on myocardial ischemia/reperfusion (MI/R) injury and to investigate the antioxidant potential in vivo and in vitro. MI/R injury was induced by the occlusion of left anterior descending coronary artery for
O V Basharina et al.
Radiatsionnaia biologiia, radioecologiia, 52(6), 602-607 (2013-03-23)
The influence of UV-light (240-390 nm) at the dozes of 151 and 755 J/m2 on the intensity of processes of the lipid peroxidation, activity of lactate dehydrogenase (LDH), succinate dehydrogenase (SDH), cytochrome c oxidase and the level of the energy
Bécaye Fall et al.
Malaria journal, 12, 107-107 (2013-03-21)
In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria. Since the introduction of ACT, there have been very few reports on the level of resistance of P. falciparum to
資料
Instructions for working with enzymes supplied as ammonium sulfate suspensions
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）