K3638

Anti-KIF17 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 別名: Anti-KIF17B, Anti-KIF3X, Anti-KLP-2, Anti-OSM-3
• MDL番号: MFCD03791822
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 交差性: mouse, rat
• テクニック: indirect immunofluorescence: 1:100 using rat pheochromocytoma PC12 cell line differentiated with NGF; microarray: suitable; western blot: 1:1,000 using mouse brain cytosolic fraction
• UniProtアクセッション番号: Q99PW8
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: mouse ... Kif17(16559) ; rat ... RGD1562511(500571)

詳細

詳細

KIF17 belongs to the functionally diverse subgroup of the kinesin superfamily characterized by a N-terminal motor domain. KIF17 is specifically expressed in the brain, abundantly present in the gray matter, particularly in the hippocampus and cerebral cortex, but not in the white matter such as the optic nerve. KIF17, a dendritic specific motor protein, is localized in dendrites of pyramidal neurons, but not in axons or nuclei of the cerebral cortex.

免疫原

synthetic peptide corresponding to amino acids 589-606 of mouse KIF17 conjugated to KLH.

アプリケーション

Anti-KIF17 antibody produced in rabbit has been used in immunofluorescence and immunoblotting.

生物化学的／生理学的作用

The kinesin superfamily of proteins (KIFs) consists of a class of microtubule-dependent motors. They play a major role in many cellular and developmental functions. The kinesin proteins are involved in organelle transport and are primarily associated with anterograde transport of vesicles and organelles in neurons, epithelial cells, and melanosomes with bidirectional transport of mitochondria. They also mediate transport between the endoplasmic reticulum (ER) and the Golgi complex. In neurons, kinesin motors conduct vesicular transport, such as of synaptic vesicle components to axons and of neurotransmitter receptors to dendrites. KIF17 conveys (in dendrites) specific cargo vesicles that contain the glutamate receptor NR2B subunit, thus KIF17 functions as the sorting machinery for NR2B.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids