H7789

抗アセチル-ヒストンH1.4 (Ac-Lys²⁶) ウサギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• 別名: Anti-H1 Histone family, member 4, Anti-H1e, Anti-Histone 1, Anti-Histone H1b
• MDL番号: MFCD09753843
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~35 kDa
• 化学種の反応性: human
• テクニック: western blot: 0.5-1 μg/mL using acid-extracted fraction of HL60 cells
• UniProtアクセッション番号: P10412
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: acetylation (Lys26)
• 遺伝子情報: human ... HIST1H1E(3008)

詳細

詳細

In mammalian cells, four histone H1 variants (H1.2 to H1.5) are present in all somatic cells, and a fifth (H1.1) is restricted to thymus, testis, and spleen and possibly lymphocytic and neuronal cells. Histone H1.4 is di-methylated or acetylated at Lys26. Lys26 is located within the flexible N-terminal domain of H1.4, just preceding the globular domain.

免疫原

synthetic acetylated peptide corresponding to amino acids 22-33 (Ac-Lys²⁶) of human histone H1.4.

アプリケーション

Anti-acetyl-Histone H1.4 (Ac-Lys26) antibody produced in rabbit is suitable for western blot at a concentration of 0.5-1μg/mL using acid-extracted fraction of HL60 cells.

Anti-acetyl-Histone H1.4 (Ac-Lys²⁶) antibody produced in rabbit has been used in western blotting.

生物化学的／生理学的作用

H1.4 at lysine residue 26 represses transcription. Linker histone H1 binds to DNA between nucleosomal core particles and is involved in establishing and maintaining higher order chromatin structures. Histone modifications are thought to play an important role in cancer and disease.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)