H6649

ハービマイシンA Streptomyces hygroscopicus由来

≥95% (HPLC), powder

• 実験式（ヒル表記法）: C₃₀H₄₂N₂O₉
• CAS番号: 70563-58-5
• 分子量: 574.66
• Beilstein: 4834067
• MDL番号: MFCD00151702
• UNSPSCコード: 12352200
• PubChem Substance ID: 24895756
• NACRES: NA.77

特性

• 由来生物: Streptomyces hygroscopicus
• 品質水準: 200
• アッセイ: ≥95% (HPLC)
• フォーム: powder
• 色: yellow
• 溶解性: DMSO: 7.5 mg/mL
• 抗生物質活性スペクトル: viruses
• 作用機序: enzyme | inhibits
• 保管温度: −20°C
• SMILES記法: CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O
• InChI: 1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
• InChI Key: MCAHMSDENAOJFZ-BVXDHVRPSA-N

詳細

詳細

DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.

Herbimycin A from Streptomyces hygroscopicus is a benzoquinoid ansamycin antibiotic. It is an analog of geldanamycin.

アプリケーション

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells and rat intestinal epithelial cells. It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.

生物化学的／生理学的作用

Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.

タンパク質チロシンキナ-ゼを阻害する抗生物質です。ハ-ビマイシンAは、血管形成の強力なインヒビタ-です。

注意

吸湿性で光に不安定です。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)