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由来生物
human
品質水準
リコンビナント
expressed in E. coli
アッセイ
≥95% (SDS-PAGE)
形状
lyophilized powder
UniProtアクセッション番号
アプリケーション
cell analysis
保管温度
−20°C
遺伝子情報
human ... LGALS1(3956)
詳細
Galectin-1 is a member of the family of animal lectins, which selectively binds β-galactoside residues.
アプリケーション
A common function of galectins is to cross-link structures containing N-acetyl-lactosamine located at the cell surface and within the extracellular matrix. They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. They have variable affinity for more complex oligosaccharides. Other activities of galectin-1 include cell differentiation and inhibition of CD45 protein phosphatase activity.
生物化学的／生理学的作用
Galectin-1 has been implicated in metastasis and aggregation of cancer cells based on its association with the glycoprotein 90K. Galectin-1 may play a significant role in cancer through apoptosis, cell adhesion, migration, cell cycle regulation and tumor evasion of immune responses.
Galectin-1 has been implicated in metastasis and aggregation of cancer cells based on its association with the glycoprotein 90K. Galectin-1 may play a significant role in cancer through apoptosis, cell adhesion and migration, regulation of the cell cycle and tumor evasion of immune responses.
物理的形状
凍結乾燥品(8 mM DTT、150 mMラクト-ス含有の5 mg/mL PBS溶液から調整)
保管分類コード
13 - Non Combustible Solids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
G7420-VAR:
G7420-150UG:
G7420-BULK:
G7420-150UG-PW:
G7420-250UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
F Archambeaud-Mouveroux et al.
Gastroenterologie clinique et biologique, 11(1), 93-95 (1987-01-01)
A case of secondary syphilitic hepatitis is reported. A 49-year old woman was admitted for weight-loss, fever, hepatomegaly and splenomegaly. Diagnosis of syphilitic hepatitis was based on cholestasis associated with positive serologic tests for syphilis without other immunological disturbances. Biopsy
Antonino Grassadonia et al.
Glycoconjugate journal, 19(7-9), 551-556 (2004-02-06)
Galectins and their ligands have been implicated in cell transformation and cancer metastasis, and found to have prognostic value. Mac-2 BP, also known as 90K, is a highly glycosylated, secreted protein extensively studied in human cancer, which binds galectin-1, galectin-3
Zanka Bojić-Trbojević et al.
Histochemistry and cell biology, 142(5), 541-553 (2014-05-24)
Mucins are multifunctional highly glycosylated proteins expressed by the female reproductive tract. Differential expression of MUC1 and MUC15 has been shown in trophoblast. This study was undertaken to establish the distribution of mucin(s) in cytotrophoblast cell cultures using anti-bovine submaxillary
V D Yakushina et al.
Molecular and cellular biochemistry, 398(1-2), 245-249 (2014-10-09)
CD4(+) T cells orchestrate the immune response by differentiating into T helper (Th) or regulatory (Treg) cell subsets that secrete distinct sets of cytokines. They also play a critical role in the pathogenesis of autoimmunity, asthma, allergy and, likely, cancer.
Sandra Thiemann et al.
The Journal of biological chemistry, 290(37), 22662-22677 (2015-07-29)
During inflammation, dendritic cells emigrate from inflamed tissue across the lymphatic endothelium into the lymphatic vasculature and travel to regional lymph nodes to initiate immune responses. However, the processes that regulate dendritic cell tissue egress and migration across the lymphatic
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