5.05823

Galectin-1 Antagonist, DB21

• 別名: Galectin-1 Antagonist, DB21, SVQNvaKL-[DBF]-IIVKLNA
• 実験式（ヒル表記法）: C₈₃H₁₃₂N₁₈O₁₇
• 分子量: 1654.05
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• 形状: powder
• 有効性: 3 μM IC₅₀
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 10 mg/mL
• 保管温度: −20°C

詳細

詳細

A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC₅₀ = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.

A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC₅₀ = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.

生物化学的／生理学的作用

Primary Target
Galectin-1

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

シーケンス

SVQMKNva-[DBF]-IIVKLNA

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Dings, R.P., et al, 2013, J. Pharm. Exp. Ther.344, 589.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable